Mazdutide
Mazdutide from the Nexus GLP-1 & Metabolic catalog, supplied for controlled in-vitro research workflows.
Ships from the US with tracking.
Catalog active: Catalog pricing is active. Live warehouse counts are not published.
- Lot-specific COA
- HPLC + MS fields
- Batch archived
For in-vitro research use only. Not for human consumption.
Mazdutide (IBI362) is a dual-acting peptide that activates both GLP-1 and glucagon receptors. Unlike Tirzepatide (GIP/GLP-1), Mazdutide pairs GLP-1 signaling with glucagon receptor agonism, which may stimulate hepatic energy expenditure and fat oxidation through distinct pathways.
Mazdutide definition
Mazdutide is a synthetic dual glucagon / GLP-1 receptor agonist peptide studied in preclinical research models for incretin and glucagon-pathway pharmacology. Structurally related to oxyntomodulin, mazdutide engages both glucagon receptors (GCGR) and GLP-1 receptors (GLP-1R) with distinct affinities. Research use only.
No sequence is listed in the current catalog record for this product.
- CAS
- 2259884-03-0
- MW
- 4476 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C207H317N45O65
- Purity
- 99.51%
- Form
- Lyophilized powder
- Class
- Dual GLP-1/Glucagon Receptor Agonist
The dossier.
Compound Overview
Mazdutide (IBI362) is a dual-acting peptide studied for activation of both GLP-1 and glucagon receptors. While Tirzepatide is categorized as a GIP/GLP-1 agonist, Mazdutide combines GLP-1 signaling with glucagon receptor agonism, creating a distinct research model for examining hepatic energy expenditure and fat oxidation pathways in controlled laboratory systems.
Research Background & Published Literature
Mazdutide was developed by Innovent Biologics and Eli Lilly. Published Phase 2/3 clinical trial literature in Lancet Diabetes & Endocrinology has increased research attention on dual GLP-1/glucagon signaling as a mechanistic approach separate from GIP/GLP-1 combination research.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Ji et al. (2025) — N Engl J Med
- Zhang et al. (2024) — Diabetes Care
- Ji et al. (2022) — EClinicalMedicine
Storage, Handling & Stability Guidelines
Use the applicable lot/source record for storage of unopened material. Any diluent selection, preparation, temperature, aliquoting, or post-reconstitution hold conditions must be established by a qualified laboratory under a validated SOP; this page does not establish a stability window.
- Keep time at ambient temperature as short as practical during handling to support compound integrity.
- Reseal vials promptly after each withdrawal to limit moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.
Quality Assurance & Lab Verification
A finalized public Certificate of Analysis is available for this catalog item. Review the public COA for the applicable lot. Lot-specific identifiers, assay values, and methods are maintained in that record and are not repeated in this product dossier.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Laboratories should follow their validated SOP together with any handling fields published for the represented product or lot; no universal prepared-solution condition is inferred here.
Compound details.
- CAS Number
- 2259884-03-0
- Molecular Weight
- 4476 g/mol
- Class
- Dual GLP-1 / glucagon agonist
- Receptor targets
- GLP-1R + GCGR
Research context.
Studied in preclinical research models examining dual-receptor incretin pharmacology, glucagon-pathway signaling research, and comparator research against single-receptor agonists (semaglutide, liraglutide) and triple-receptor agonists (retatrutide). Research use only.
Verification standard.
Certificate information is lot-specific. A finalized public record shows only the methods, fields, and results present for that named lot. A pending certificate state exposes no assay values and must not be interpreted as analytical verification. Review Nexus lab verification.
Analytical record.
- Reported HPLC purity
- 99.51%
- Retention time
- 17.00 min
- Observed mass
- 4515.84 Da
- Batch
- APX-2026-0315-M
The normalized Certificate of Analysis publishes only the lot-specific fields represented in the public record. It is not an originating laboratory report or raw instrument file.
View certificate of analysis - batch APX-2026-0315-M- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
Dual GLP-1/glucagon receptor agonist peptide (also known as IBI362/LY3305677)
Technical specifications.
- Product Name: Mazdutide 10mg
- Classification: Dual GLP-1/Glucagon Receptor Agonist
- Structural Description: Dual GLP-1/glucagon receptor agonist peptide (also known as IBI362/LY3305677)
- CAS Number: 2259884-03-0
- Molecular Weight: 4476 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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Mazdutide research FAQ.
What is Mazdutide used for in research?
Mazdutide is supplied for controlled in-vitro research workflows in the GLP-1 & Metabolic category. It is not labeled for human or veterinary use.
Does Mazdutide have a finalized analytical record?
Mazdutide has a finalized Nexus Lab Verified record that reports 99.51% HPLC area-percent purity for the represented batch. Other fields are shown only where present.
Which Mazdutide variants are published?
Published Nexus variants include 5mg, 10mg.
Does Mazdutide include a COA?
Yes. The current Nexus record links Mazdutide to finalized batch APX-2026-0315-M.