Semax
Semax from the Nexus Cognitive & Nootropic catalog, supplied for controlled in-vitro research workflows.
In stock: 5mg is in stock.
For in-vitro research use only. Not for human consumption.
Semax is a synthetic heptapeptide derived from the ACTH (4-10) fragment with a stabilizing Pro-Gly-Pro C-terminal modification. It modulates BDNF expression, dopaminergic signaling, and neurotrophic factor pathways without affecting adrenal cortisol production. Research examines its neuroprotective and cognitive-enhancing properties.
No sequence is listed in the current catalog record for this product.
- CAS
- 80714-61-0
- MW
- 813.93 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C37H51N9O10S
- Purity
- 99.51%
- Form
- Lyophilized powder
- Class
- Nootropic/Neuroprotective Peptide (ACTH Analog)
This lyophilized research material is commonly paired with bacteriostatic water for reconstitution workflows.
Bacteriostatic water for reconstitutionThe dossier.
Compound Overview
Semax is a synthetic heptapeptide based on the ACTH (4-10) fragment and stabilized with a Pro-Gly-Pro C-terminal modification. In controlled research models, Semax modulates BDNF expression, dopaminergic signaling, and neurotrophic factor pathways without affecting adrenal cortisol production. Laboratory studies examine neuroprotection-related and cognition-related experimental endpoints.
Research Background & Published Literature
Semax was developed at the Institute of Molecular Genetics, Russian Academy of Sciences, and published research has appeared in Brain Research and Doklady Biological Sciences. Nexus supplies Semax only as an in-vitro research reagent and does not offer it for human, veterinary, therapeutic, diagnostic, or disease-related use.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Dmitrieva et al. (2010) — Cell Mol Neurobiol
- Stavchanskiĭ et al. (2011) — Mol Biol (Mosk)
- Gusev et al. (2018) — Zh Nevrol Psikhiatr Im S S Korsakova
Storage, Handling & Stability Guidelines
For long-term stability, keep lyophilized Semax material stored at -20°C. After reconstitution with sterile diluent, refrigerate at 2–8°C and reduce freeze-thaw exposure by aliquoting working volumes according to validated laboratory SOPs.
- Keep ambient-temperature handling time as short as practical to support compound integrity.
- Reseal vials promptly after each withdrawal to limit moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.
Lab Verification
Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Compounds are supplied as lyophilized research material — follow the storage and reconstitution guidance on the product page and its Certificate of Analysis.
Compound details.
- CAS Number
- 80714-61-0
- Molecular Weight
- 813.93 g/mol
- Molecular Formula
- C₃₇H₅₁N₉O₁₀S
- Class
- Nootropic/Neuroprotective Peptide (ACTH Analog)
- Purity
- ≥99% purity
- Physical Form
- Lyophilized powder
- Storage
- Store at -20°C (long term). Refrigerate after reconstitution.
Research context.
Developed at the Institute of Molecular Genetics, Russian Academy of Sciences. Approved as a pharmaceutical in Russia for cognitive and neurological applications. Published studies in Brain Research and Doklady Biological Sciences.
Verification standard.
Independently verified Nexus Laboratory batches ship with a Certificate of Analysis documenting HPLC purity (target ≥98%), mass spectrometry identity (expected versus observed mass), and endotoxin context where applicable — verified by independent third-party laboratories and publicly archived; lots awaiting final documentation are labeled certificate pending instead of showing assay values. Review Nexus lab verification.
HPLC trace.
- HPLC purity
- 99.51%
- Retention time
- 7 min
- Batch
- NEX-SEMAX-2026-0077
The full reverse-phase HPLC chromatogram, peak integration table, and mass-spectrometry identity confirmation for this batch are published on the certificate of analysis.
View certificate of analysis - batch NEX-SEMAX-2026-0077- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
7-amino acid synthetic peptide derived from ACTH (4-10) with Pro-Gly-Pro extension
Storage: Store at -20°C (long term). Refrigerate after reconstitution.
Technical specifications.
- Product Name: Semax
- Classification: Nootropic/Neuroprotective Peptide (ACTH Analog)
- Structural Description: 7-amino acid synthetic peptide derived from ACTH (4-10) with Pro-Gly-Pro extension
- CAS Number: 80714-61-0
- Molecular Weight: 813.93 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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Research notes.
Semax research FAQ.
What is Semax used for in research?
Semax is supplied for controlled in-vitro research workflows in the Cognitive & Nootropic category. It is not labeled for human or veterinary use.
Is Semax HPLC verified?
Semax has a finalized Nexus Lab Verified record with 99.51% HPLC purity context in the current COA data.
Which Semax sizes are available?
Current Nexus variants include 5mg, 10mg, 30mg.
Does Semax include a COA?
Yes. The current Nexus record links Semax to verified batch NEX-SEMAX-2026-0077.