Semax
Semax from the Nexus Cognitive & Nootropic catalog, supplied for controlled in-vitro research workflows.
Ships from the US with tracking.
Catalog active: Catalog pricing is active. Live warehouse counts are not published.
- Lot-specific COA
- HPLC + MS fields
- Batch archived
For in-vitro research use only. Not for human consumption.
Semax is a synthetic heptapeptide derived from the ACTH (4-10) fragment with a stabilizing Pro-Gly-Pro C-terminal modification. It modulates BDNF expression, dopaminergic signaling, and neurotrophic factor pathways without affecting adrenal cortisol production. Research examines its neuroprotective and cognitive-enhancing properties.
No sequence is listed in the current catalog record for this product.
- CAS
- 80714-61-0
- MW
- 813.93 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C37H51N9O10S
- Purity
- 99.51%
- Form
- Lyophilized powder
- Class
- Nootropic/Neuroprotective Peptide (ACTH Analog)
The dossier.
Compound Overview
Semax is a synthetic heptapeptide based on the ACTH (4-10) fragment and stabilized with a Pro-Gly-Pro C-terminal modification. In controlled research models, Semax modulates BDNF expression, dopaminergic signaling, and neurotrophic factor pathways without affecting adrenal cortisol production. Laboratory studies examine neuroprotection-related and cognition-related experimental endpoints.
Research Background & Published Literature
Semax was developed at the Institute of Molecular Genetics, Russian Academy of Sciences, and published research has appeared in Brain Research and Doklady Biological Sciences. Nexus supplies Semax only as an in-vitro research reagent and does not offer it for human, veterinary, therapeutic, diagnostic, or disease-related use.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Dmitrieva et al. (2010) — Cell Mol Neurobiol
- Stavchanskiĭ et al. (2011) — Mol Biol (Mosk)
- Gusev et al. (2018) — Zh Nevrol Psikhiatr Im S S Korsakova
Storage, Handling & Stability Guidelines
Use the applicable lot/source record for storage of unopened material. Any diluent selection, preparation, temperature, aliquoting, or post-reconstitution hold conditions must be established by a qualified laboratory under a validated SOP; this page does not establish a stability window.
- Keep ambient-temperature handling time as short as practical to support compound integrity.
- Reseal vials promptly after each withdrawal to limit moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.
Quality Assurance & Lab Verification
A finalized public Certificate of Analysis is available for this catalog item. Review the public COA for the applicable lot. Lot-specific identifiers, assay values, and methods are maintained in that record and are not repeated in this product dossier.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Laboratories should follow their validated SOP together with any handling fields published for the represented product or lot; no universal prepared-solution condition is inferred here.
Compound details.
- CAS Number
- 80714-61-0
- Molecular Weight
- 813.93 g/mol
- Molecular Formula
- C₃₇H₅₁N₉O₁₀S
- Class
- Nootropic/Neuroprotective Peptide (ACTH Analog)
Research context.
Developed at the Institute of Molecular Genetics, Russian Academy of Sciences. Approved as a pharmaceutical in Russia for cognitive and neurological applications. Published studies in Brain Research and Doklady Biological Sciences.
Verification standard.
Certificate information is lot-specific. A finalized public record shows only the methods, fields, and results present for that named lot. A pending certificate state exposes no assay values and must not be interpreted as analytical verification. Review Nexus lab verification.
Analytical record.
- Reported HPLC purity
- 99.51%
- Retention time
- 7.00 min
- Observed mass
- 813.97 Da
- Batch
- APX-2026-0320-S
The normalized Certificate of Analysis publishes only the lot-specific fields represented in the public record. It is not an originating laboratory report or raw instrument file.
View certificate of analysis - batch APX-2026-0320-S- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
7-amino acid synthetic peptide derived from ACTH (4-10) with Pro-Gly-Pro extension
Technical specifications.
- Product Name: Semax
- Classification: Nootropic/Neuroprotective Peptide (ACTH Analog)
- Structural Description: 7-amino acid synthetic peptide derived from ACTH (4-10) with Pro-Gly-Pro extension
- CAS Number: 80714-61-0
- Molecular Weight: 813.93 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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Research notes.
Semax research FAQ.
What is Semax used for in research?
Semax is supplied for controlled in-vitro research workflows in the Cognitive & Nootropic category. It is not labeled for human or veterinary use.
Does Semax have a finalized analytical record?
Semax has a finalized Nexus Lab Verified record that reports 99.51% HPLC area-percent purity for the represented batch. Other fields are shown only where present.
Which Semax variants are published?
Published Nexus variants include 5mg, 10mg, 30mg.
Does Semax include a COA?
Yes. The current Nexus record links Semax to finalized batch APX-2026-0320-S.