For in-vitro research use only. Not for human consumption.
PE 22-28
PE-22-28 is a synthetic peptide that inhibits the TREK-1 potassium channel (two-pore domain K+ channel). TREK-1 inhibition has been linked to increased serotonergic signaling and BDNF expression. It is studied as a potential rapid-onset antidepressant-like compound and nootropic in preclinical research models.
PE 22-28 definition
PE 22-28 is a synthetic 7-amino-acid peptide derived from spadin (a sortilin-derived peptide). Research models examine its interaction with TREK-1 potassium channels, which are studied in CNS-pathway research models. The compound is a research-context spadin-pathway analog. Research use only. Supplied by Nexus Laboratory with batch-level certificate of analysis documenting HPLC purity, mass spectrometry identity, and endotoxin screening.
No sequence is listed in the current catalog record for this product.
- CAS
- 1801959
- MW
- ~850 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C35H55N11O9
- Purity
- 99.62%
- Form
- Lyophilized powder
- Class
- TREK-1 Channel Inhibitor / Nootropic Peptide
Reconstitution calculator
Estimate vial concentration and aliquot volume from the selected vial mass, solvent volume, and target research amount.
Calculations are for lab planning only and do not replace the product COA, protocol requirements, or qualified professional review. Confirm solvent compatibility before use.
Compound details.
- Molecular Weight
- ~826.04 g/mol
- Class
- Spadin-derived peptide (residues 22-28)
- Sequence length
- 7 residues
- Research target
- TREK-1 potassium channel
Research context.
Studied in preclinical research models examining TREK-1 channel pharmacology, CNS signaling research, and spadin-pathway research. Research use only.
Verification standard.
Every Nexus Laboratory batch ships with a Certificate of Analysis documenting HPLC purity (target ≥98%), mass spectrometry identity (expected versus observed mass), and endotoxin screening — verified by third-party laboratory testing and publicly archived. Review Nexus lab verification.
PE 22-28 is part of the Nexus Cognitive & Nootropic catalog. Neuroactive, nootropic, and cognitive research compounds. Each listed variant is priced from the consolidated Nexus catalog and intended for qualified research use only.
TODO-COPY: replace with real compound-specific narrative.
The chemistry.
7-amino acid peptide fragment of the prion protein-derived compound, spadin analog
Storage: Store at -20°C (long term). Refrigerate after reconstitution.
Technical specifications.
- Product Name: PE-22-28 5mg
- Classification: TREK-1 Channel Inhibitor / Nootropic Peptide
- Structural Description: 7-amino acid peptide fragment of the prion protein-derived compound, spadin analog
- Molecular Weight: ~850 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
HPLC trace preview.
Related research compounds
Same category, mechanism overlap, and common research stack pairings.
PE 22-28 research FAQ.
What is PE 22-28 used for in research?
PE 22-28 is supplied for controlled in-vitro research workflows in the Cognitive & Nootropic category. It is not labeled for human or veterinary use.
Is PE 22-28 HPLC verified?
PE 22-28 is listed with Nexus lab verification. Current catalog records show 99.62% purity context where batch COA data is available.
Which PE 22-28 sizes are available?
Current Nexus variants include 10mg.
Does PE 22-28 include a COA?
Yes. The current Nexus record links PE 22-28 to batch NEX-PE-22-28-2026-0066.