PE 22-28
PE 22-28 from the Nexus Cognitive & Nootropic catalog, supplied for controlled in-vitro research workflows.
In stock: 10mg is in stock.
For in-vitro research use only. Not for human consumption.
PE-22-28 is a synthetic peptide that inhibits the TREK-1 potassium channel (two-pore domain K+ channel). TREK-1 inhibition has been linked to increased serotonergic signaling and BDNF expression. It is studied as a potential rapid-onset antidepressant-like compound and nootropic in preclinical research models.
PE 22-28 definition
PE 22-28 is a synthetic 7-amino-acid peptide derived from spadin (a sortilin-derived peptide). Research models examine its interaction with TREK-1 potassium channels, which are studied in CNS-pathway research models. The compound is a research-context spadin-pathway analog. Research use only. Independently verified Nexus lots publish a Certificate of Analysis documenting HPLC purity, mass spectrometry identity, and endotoxin screening; pending lots are labeled certificate pending.
No sequence is listed in the current catalog record for this product.
- CAS
- 1801959-12-5
- MW
- 773.9 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C35H55N11O9
- Purity
- 99.62%
- Form
- Lyophilized powder
- Class
- TREK-1 Channel Inhibitor / Nootropic Peptide
This lyophilized research material is commonly paired with bacteriostatic water for reconstitution workflows.
Pair with bacteriostatic waterThe dossier.
Compound Overview
PE-22-28 is a synthetic peptide that inhibits the TREK-1 potassium channel (two-pore domain K+ channel). TREK-1 inhibition has been linked to increased serotonergic signaling and BDNF expression. In preclinical research models, the compound is studied in relation to rapid-onset antidepressant-like and nootropic research pathways.
Research Background & Published Literature
PE-22-28 comes from the spadin research reported in Nature Medicine by Mazella et al. (2010) at IPMC-CNRS. The compound is an optimized fragment used to examine TREK-1-mediated signaling and mood-related neurotransmitter pathways with improved stability in controlled research settings.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
Storage, Handling & Stability Guidelines
Store lyophilized PE 22-28 at -20°C for long-term stability. After reconstitution with sterile diluent, keep material refrigerated at 2–8°C and limit freeze-thaw exposure by aliquoting working volumes according to institutional standard operating procedures.
- Keep time at ambient temperature as brief as practical during handling to support compound integrity.
- Reseal vials promptly after each withdrawal to reduce moisture exposure.
- Use appropriate personal protective equipment and follow your institution's chemical safety protocols at all times.
- For traceability, label aliquots with compound name, concentration, reconstitution date, and operator initials.
Lab Verification
Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Compounds are supplied as lyophilized research material — follow the storage and reconstitution guidance on the product page and its Certificate of Analysis.
Compound details.
- Molecular Weight
- 773.9 g/mol
- Class
- Spadin-derived peptide (residues 22-28)
- Sequence length
- 7 residues
- Research target
- TREK-1 potassium channel
Research context.
Studied in preclinical research models examining TREK-1 channel pharmacology, CNS signaling research, and spadin-pathway research. Research use only.
Verification standard.
Independently verified Nexus Laboratory batches ship with a Certificate of Analysis documenting HPLC purity (target ≥98%), mass spectrometry identity (expected versus observed mass), and endotoxin context where applicable — verified by independent third-party laboratories and publicly archived; lots awaiting final documentation are labeled certificate pending instead of showing assay values. Review Nexus lab verification.
HPLC trace.
- HPLC purity
- 99.62%
- Retention time
- 8 min
- Batch
- NEX-PE-22-28-2026-0066
The full reverse-phase HPLC chromatogram, peak integration table, and mass-spectrometry identity confirmation for this batch are published on the certificate of analysis.
View certificate of analysis - batch NEX-PE-22-28-2026-0066- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
7-amino acid peptide fragment of the prion protein-derived compound, spadin analog
Storage: Store at -20°C (long term). Refrigerate after reconstitution.
Technical specifications.
- Product Name: PE-22-28 5mg
- Classification: TREK-1 Channel Inhibitor / Nootropic Peptide
- Structural Description: 7-amino acid peptide fragment of the prion protein-derived compound, spadin analog
- Molecular Weight: 773.9 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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PE 22-28 research FAQ.
What is PE 22-28 used for in research?
PE 22-28 is supplied for controlled in-vitro research workflows in the Cognitive & Nootropic category. It is not labeled for human or veterinary use.
Is PE 22-28 HPLC verified?
PE 22-28 has a finalized Nexus Lab Verified record with 99.62% HPLC purity context in the current COA data.
Which PE 22-28 sizes are available?
Current Nexus variants include 10mg.
Does PE 22-28 include a COA?
Yes. The current Nexus record links PE 22-28 to verified batch NEX-PE-22-28-2026-0066.