VIP

Compound Overview

Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide described in research literature as an activator of VPAC1 and VPAC2 receptors (class B GPCRs). Controlled studies use VIP to examine vasodilation, smooth muscle relaxation, neuromodulation, circadian rhythm regulation, and immune signaling across multiple organ systems.

Research Background & Published Literature

VIP was discovered in 1970 by Said and Mutt, and the compound has since appeared in thousands of published studies, including work in Journal of Neuroimmunology, Endocrinology, and Peptides. In laboratory contexts, VIP remains a research tool for neuroendocrine, gastrointestinal, and immunological signaling studies.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Said et al. (1970) — Nature
• Mutt et al. (1974) — Eur J Biochem
• Mutt (1988) — Ann N Y Acad Sci

Storage, Handling & Stability Guidelines

For long-term stability, store lyophilized VIP material at -20°C. After reconstitution with sterile diluent, keep research material refrigerated at 2–8°C and reduce repeated freeze-thaw exposure by aliquoting working volumes according to validated laboratory SOPs.

• Keep ambient-temperature handling windows brief to help preserve compound integrity.
• Limit moisture exposure by resealing vials promptly after each withdrawal.
• Wear appropriate personal protective equipment and follow institutional chemical safety protocols during all handling steps.
• Maintain traceability by labeling aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.