PT-141
PT-141 from the Nexus Sexual Health catalog, supplied for controlled in-vitro research workflows.
In stock: 10mg is in stock.
For in-vitro research use only. Not for human consumption.
PT-141 (Bremelanotide) is a cyclic heptapeptide metabolite of Melanotan II. It activates melanocortin receptors MC3R and MC4R with relative selectivity over MC1R. Research focuses on its central nervous system melanocortin signaling, particularly in hypothalamic pathways regulating sexual arousal and behavior.
No sequence is listed in the current catalog record for this product.
- CAS
- 189691-06-3
- MW
- 1025.18 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C50H68N14O10
- Purity
- 99.74%
- Form
- Lyophilized powder
- Class
- Melanocortin Receptor Agonist (MC3R/MC4R Selective)
This lyophilized research material is commonly paired with bacteriostatic water for reconstitution workflows.
Browse bacteriostatic waterThe dossier.
Compound Overview
PT-141 (Bremelanotide) is a cyclic heptapeptide metabolite of Melanotan II. Research literature describes activation at melanocortin receptors MC3R and MC4R with relative selectivity over MC1R. In controlled laboratory models, PT-141 is studied for central nervous system melanocortin signaling, particularly hypothalamic pathways associated with sexual arousal and behavior.
Research Background & Published Literature
Bremelanotide appears in regulated clinical literature under separate product contexts; Nexus PT-141 is not supplied for clinical, human, veterinary, therapeutic, diagnostic, treatment, or disease-related use. Research publications in journals such as Journal of Sexual Medicine and Journal of Urology examine central nervous system melanocortin signaling as distinct from peripheral melanogenesis pathways.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Kingsberg et al. (2019) — Obstet Gynecol
- Althof et al. (2019) — J Sex Med
- Cipriani et al. (2023) — Expert Opin Pharmacother
Storage, Handling & Stability Guidelines
Store lyophilized PT-141 at -20°C for long-term stability. After reconstitution with sterile diluent, hold research material at 2–8°C and limit freeze-thaw cycles by aliquoting working volumes according to established laboratory SOPs.
- Keep ambient-temperature exposure as brief as practical during handling to support compound integrity.
- Reseal vials promptly after each withdrawal to limit moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.
Lab Verification
Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Compounds are supplied as lyophilized research material — follow the storage and reconstitution guidance on the product page and its Certificate of Analysis.
Compound details.
- CAS Number
- 189691-06-3
- Molecular Weight
- 1025.18 g/mol
- Molecular Formula
- C₅₀H₆₈N₁₄O₁₀
- Class
- Melanocortin Receptor Agonist (MC3R/MC4R Selective)
- Purity
- ≥99% purity
- Physical Form
- Lyophilized powder
- Storage
- Store at -20°C (long term). Refrigerate after reconstitution.
Research context.
The branded clinical product Vyleesi is approved for hypoactive sexual desire disorder (HSDD) in adult women; This material is supplied strictly for in-vitro research use only. Published in Journal of Sexual Medicine and Journal of Urology. Research examines CNS melanocortin signaling as distinct from peripheral melanogenesis pathways.
Verification standard.
Independently verified Nexus Laboratory batches ship with a Certificate of Analysis documenting HPLC purity (target ≥98%), mass spectrometry identity (expected versus observed mass), and endotoxin context where applicable — verified by independent third-party laboratories and publicly archived; lots awaiting final documentation are labeled certificate pending instead of showing assay values. Review Nexus lab verification.
HPLC trace.
- HPLC purity
- 99.74%
- Retention time
- 9 min
- Batch
- NEX-PT-141-2026-0071
The full reverse-phase HPLC chromatogram, peak integration table, and mass-spectrometry identity confirmation for this batch are published on the certificate of analysis.
View certificate of analysis - batch NEX-PT-141-2026-0071- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
Cyclic 7-amino acid peptide (Bremelanotide), metabolite of Melanotan II
Storage: Store at -20°C (long term). Refrigerate after reconstitution.
Technical specifications.
- Product Name: PT-141 10mg
- Classification: Melanocortin Receptor Agonist (MC3R/MC4R Selective)
- Structural Description: Cyclic 7-amino acid peptide (Bremelanotide), metabolite of Melanotan II
- CAS Number: 189691-06-3
- Molecular Weight: 1025.18 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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PT-141 research FAQ.
What is PT-141 used for in research?
PT-141 is supplied for controlled in-vitro research workflows in the Sexual Health category. It is not labeled for human or veterinary use.
Is PT-141 HPLC verified?
PT-141 has a finalized Nexus Lab Verified record with 99.74% HPLC purity context in the current COA data.
Which PT-141 sizes are available?
Current Nexus variants include 10mg.
Does PT-141 include a COA?
Yes. The current Nexus record links PT-141 to verified batch NEX-PT-141-2026-0071.