5-amino-1mq
5-amino-1mq from the Nexus Mitochondrial & Energy catalog, supplied for controlled in-vitro research workflows.
In stock: 5mg is in stock.
For in-vitro research use only. Not for human consumption.
5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide using SAM as a methyl donor. By inhibiting NNMT, 5-Amino-1MQ may increase intracellular NAD+ levels and SAM availability, linking it to sirtuin activity, methylation capacity, and adipocyte differentiation research.
No sequence is listed in the current catalog record for this product.
- CAS
- 685079-15-6
- MW
- 159.21 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C10H11N2
- Purity
- 99.60%
- Form
- Lyophilized powder
- Class
- NNMT Inhibitor / Metabolic Research Compound
This lyophilized research material is commonly paired with bacteriostatic water for reconstitution workflows.
Bacteriostatic water for reconstitutionThe dossier.
Compound Overview
5-Amino-1MQ is a selective inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme responsible for methylating nicotinamide with SAM as the methyl donor. In controlled research models, NNMT inhibition by 5-Amino-1MQ may increase intracellular NAD+ levels and SAM availability, making the compound relevant to investigations involving sirtuin activity, methylation capacity, and adipocyte differentiation.
Research Background & Published Literature
5-Amino-1MQ has been reported in Biochemical Pharmacology and studied by researchers at University of Texas Medical Branch. NNMT is examined as a target in metabolic disease and cancer research, and 5-Amino-1MQ is frequently used as a pharmacological tool compound in that research context.
For more detail on mechanism of action, signaling pathways, and controlled experimental applications, researchers can review the peer-reviewed literature below:
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
Storage, Handling & Stability Guidelines
For long-term stability, store lyophilized material at -20°C. Once reconstituted with sterile diluent, keep the preparation refrigerated at 2–8°C and reduce freeze-thaw exposure by separating working volumes according to your laboratory's standard operating procedures.
- Limit ambient-temperature handling time to help maintain compound integrity.
- Reseal vials promptly after each withdrawal to reduce moisture exposure.
- Wear appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label aliquots with compound name, concentration, reconstitution date, and operator initials.
Lab Verification
Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Compounds are supplied as lyophilized research material — follow the storage and reconstitution guidance on the product page and its Certificate of Analysis.
Compound details.
- CAS Number
- 685079-15-6
- Molecular Weight
- 159.21 g/mol
- Molecular Formula
- C₁₀H₁₁N₂
- Class
- NNMT Inhibitor / Metabolic Research Compound
- Purity
- ≥99% purity
- Physical Form
- Lyophilized powder
- Storage
- Store at -20°C (long term). Refrigerate after reconstitution.
Research context.
Published in Biochemical Pharmacology and by researchers at University of Texas Medical Branch. NNMT has emerged as a target in metabolic disease and cancer research, with 5-Amino-1MQ as a primary pharmacological tool compound.
Verification standard.
Independently verified Nexus Laboratory batches ship with a Certificate of Analysis documenting HPLC purity (target ≥98%), mass spectrometry identity (expected versus observed mass), and endotoxin context where applicable — verified by independent third-party laboratories and publicly archived; lots awaiting final documentation are labeled certificate pending instead of showing assay values. Review Nexus lab verification.
HPLC trace.
- HPLC purity
- 99.60%
- Retention time
- 5 min
- Batch
- NEX-5-AMINO-1MQ-2026-0001
The full reverse-phase HPLC chromatogram, peak integration table, and mass-spectrometry identity confirmation for this batch are published on the certificate of analysis.
View certificate of analysis - batch NEX-5-AMINO-1MQ-2026-0001- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
Small molecule NNMT inhibitor (non-peptide), 5-amino-1-methylquinolinium
Storage: Store at -20°C (long term). Refrigerate after reconstitution.
Technical specifications.
- Product Name: 5-Amino-1MQ
- Classification: NNMT Inhibitor / Metabolic Research Compound
- Structural Description: Small molecule NNMT inhibitor (non-peptide), 5-amino-1-methylquinolinium
- CAS Number: 685079-15-6
- Molecular Weight: 159.21 Da
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: See product label for form details
- Intended Use: In-vitro research use only — not for human consumption
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5-amino-1mq research FAQ.
What is 5-amino-1mq used for in research?
5-amino-1mq is supplied for controlled in-vitro research workflows in the Mitochondrial & Energy category. It is not labeled for human or veterinary use.
Is 5-amino-1mq HPLC verified?
5-amino-1mq has a finalized Nexus Lab Verified record with 99.60% HPLC purity context in the current COA data.
Which 5-amino-1mq sizes are available?
Current Nexus variants include 5mg, 10mg, 50mg.
Does 5-amino-1mq include a COA?
Yes. The current Nexus record links 5-amino-1mq to verified batch NEX-5-AMINO-1MQ-2026-0001.