AICAR
AICAR from the Nexus Mitochondrial & Energy catalog, supplied for controlled in-vitro research workflows.
Ships from the US with tracking.
Catalog active: Catalog pricing is active. Live warehouse counts are not published.
- Lot-specific COA
- HPLC + MS fields
- Batch archived
For in-vitro research use only. Not for human consumption.
AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is a cell-permeable nucleoside that is metabolized to ZMP (AICAR monophosphate), an AMP analog that activates AMP-activated protein kinase (AMPK). AMPK is a master regulator of cellular energy homeostasis, making AICAR a widely used pharmacological tool in metabolic research.
No sequence is listed in the current catalog record for this product.
- CAS
- 2627-69-2
- MW
- 258.23 Da
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C9H14N4O5
- Purity
- 99.61%
- Form
- Lyophilized powder
- Class
- AMPK Activator / Nucleoside Analog
The dossier.
Compound Overview
AICAR (5-Aminoimidazole-4-carboxamide ribonucleoside) is a cell-permeable nucleoside. In experimental systems, it is metabolized to ZMP (AICAR monophosphate), an AMP analog that activates AMP-activated protein kinase (AMPK). Because AMPK functions as a master regulator of cellular energy homeostasis, AICAR is widely used as a pharmacological tool compound in metabolic research.
Research Background & Published Literature
AICAR is among the most frequently cited AMPK activators in published research, with thousands of studies using it as a tool compound. It has been applied in cell-culture and animal-model research involving fatty acid oxidation, glucose uptake, mitochondrial biogenesis, and exercise-mimetic signaling.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
Storage, Handling & Stability Guidelines
Use the applicable lot/source record for storage of unopened material. Any diluent selection, preparation, temperature, aliquoting, or post-reconstitution hold conditions must be established by a qualified laboratory under a validated SOP; this page does not establish a stability window.
- Keep ambient-temperature handling time as short as practical to support compound integrity.
- Reseal vials promptly after each withdrawal to limit moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.
Quality Assurance & Lab Verification
A finalized public Certificate of Analysis is available for this catalog item. Review the public COA for the applicable lot. Lot-specific identifiers, assay values, and methods are maintained in that record and are not repeated in this product dossier.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Laboratories should follow their validated SOP together with any handling fields published for the represented product or lot; no universal prepared-solution condition is inferred here.
Compound details.
- CAS Number
- 2627-69-2
- Molecular Weight
- 258.23 Da
- Molecular Formula
- C₉H₁₄N₄O₅
- Class
- AMPK Activator / Nucleoside Analog
Research context.
AICAR is one of the most cited AMPK activators in published literature, with thousands of studies using it as a tool compound. It has been used to study fatty acid oxidation, glucose uptake, mitochondrial biogenesis, and exercise-mimetic signaling in cell culture and animal models.
Verification standard.
Certificate information is lot-specific. A finalized public record shows only the methods, fields, and results present for that named lot. A pending certificate state exposes no assay values and must not be interpreted as analytical verification. Review Nexus lab verification.
Analytical record.
- Reported HPLC purity
- 99.61%
- Retention time
- 5.50 min
- Observed mass
- 258.19 Da
- Batch
- APX-2026-0403-A
The normalized Certificate of Analysis publishes only the lot-specific fields represented in the public record. It is not an originating laboratory report or raw instrument file.
View certificate of analysis - batch APX-2026-0403-A- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
5-Aminoimidazole-4-carboxamide ribonucleoside (nucleoside analog, not a peptide)
Technical specifications.
- Product Name: Aicar
- Classification: AMPK Activator / Nucleoside Analog
- Structural Description: 5-Aminoimidazole-4-carboxamide ribonucleoside (nucleoside analog, not a peptide)
- CAS Number: 2627-69-2
- Molecular Weight: 258.23 Da
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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AICAR research FAQ.
What is AICAR used for in research?
AICAR is supplied for controlled in-vitro research workflows in the Mitochondrial & Energy category. It is not labeled for human or veterinary use.
Does AICAR have a finalized analytical record?
AICAR has a finalized Nexus Lab Verified record that reports 99.61% HPLC area-percent purity for the represented batch. Other fields are shown only where present.
Which AICAR variants are published?
Published Nexus variants include 50mg, 100mg.
Does AICAR include a COA?
Yes. The current Nexus record links AICAR to finalized batch APX-2026-0403-A.