NAD+

Compound Overview

NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme present in all living cells. In experimental biology, it is studied as an electron carrier in metabolic redox reactions (glycolysis, TCA cycle, oxidative phosphorylation) and as a substrate for sirtuin deacetylases (SIRT1-7), PARPs, and CD38. Research attention commonly centers on aging, DNA repair, and mitochondrial function.

Research Background & Published Literature

NAD+ biology remains one of the most active areas in aging and metabolism research, with published work appearing in Nature, Science, Cell, and Cell Metabolism. Major laboratory research themes include NAD+ decline with age, sirtuin-mediated signaling, and metabolic pathway regulation.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Verdin (2015) — Science
• Covarrubias et al. (2021) — Nat Rev Mol Cell Biol
• Lautrup et al. (2019) — Cell Metab

Storage, Handling & Stability Guidelines

For long-term stability, store lyophilized NAD+ material at -20°C. After reconstitution with sterile diluent, keep the material refrigerated at 2–8°C and limit freeze-thaw exposure by aliquoting working volumes according to your laboratory's standard operating procedures.

• Keep ambient-temperature handling time as short as practical to support compound integrity.
• Reseal vials promptly after each withdrawal to limit moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.