Adipotide

Compound Overview

Adipotide (FTTP) is a chimeric peptide designed to selectively target the vasculature of white adipose tissue. Its design combines a prohibitin-targeting peptide motif with a proapoptotic D(KLAKLAK)2 sequence, allowing researchers to evaluate how this dual-domain construct may selectively disrupt blood supply to adipose tissue in preclinical models.

Research Background & Published Literature

In Science Translational Medicine, Barnhart et al. (2011) evaluated Adipotide in non-human primate models and reported observations involving adipose tissue vasculature. This literature frames Adipotide as a research tool for studying vascular targeting of specific tissue types under controlled experimental conditions.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Barnhart et al. (2011) — Sci Transl Med
• Kolonin et al. (2004) — Nat Med
• Hossen et al. (2013) — J Control Release

Storage, Handling & Stability Guidelines

For long-term stability, keep lyophilized Adipotide stored at -20°C. After reconstitution with sterile diluent, hold the preparation at 2–8°C and limit freeze-thaw exposure by separating working volumes according to your laboratory's standard operating procedures.

• Reduce ambient-temperature exposure during handling to help preserve compound integrity.
• Reseal vials promptly after each withdrawal to limit moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.