Ara-290
Ara-290 from the Nexus Specialty Research catalog, supplied for controlled in-vitro research workflows.
Ships from the US with tracking.
Catalog active: Catalog pricing is active. Live warehouse counts are not published.
- Lot-specific COA
- HPLC + MS fields
- Batch archived
For in-vitro research use only. Not for human consumption.
ARA290 (Cibinetide) is an 11-amino acid peptide derived from the helix B surface of erythropoietin (EPO). In research contexts, it selectively activates the Innate Repair Receptor (IRR), a heteromer of EPO receptor and CD131 (β-common receptor), without stimulating erythropoiesis. This receptor selectivity supports laboratory studies of tissue-protective signaling independent of red blood cell production.
Ara-290 definition
ARA-290 (cibinetide) is an 11-amino-acid synthetic peptide derived from the helix-B surface of erythropoietin. Research models have examined its interaction with the innate-repair receptor (IRR; CD131 / β-common subunit) without engaging classical erythropoietin receptors. The compound is studied in preclinical tissue-protection research without erythropoiesis side effects characteristic of EPO. Research use only.
No sequence is listed in the current catalog record for this product.
- CAS
- 1208243-50-8
- MW
- 1257.3 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- Not listed
- Purity
- 99.79%
- Form
- Not listed
- Class
- Specialty Research
The dossier.
Compound Overview
ARA290 (Cibinetide) is an 11-amino acid peptide derived from the helix B surface of erythropoietin (EPO). In research contexts, it selectively activates the Innate Repair Receptor (IRR), a heteromer of EPO receptor and CD131 (β-common receptor), without stimulating erythropoiesis. This receptor selectivity supports laboratory studies of tissue-protective signaling independent of red blood cell production.
Research Background & Published Literature
ARA290 has been discussed in Molecular Medicine and other journals, with published research covering neuroprotection, metabolic neuropathy, and anti-inflammatory signaling models. Clinical-trial literature has also investigated the compound in sarcoidosis and diabetic neuropathy contexts; Nexus supplies this catalog item only as an in-vitro research reagent and not for diagnostic, therapeutic, human, or veterinary use.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Brines et al. (2015) — Mol Med
- van Velzen et al. (2014) — Expert Opin Investig Drugs
- Zhang et al. (2016) — Peptides
Storage, Handling & Stability Guidelines
Use the applicable lot/source record for storage of unopened material. Any diluent selection, preparation, temperature, aliquoting, or post-reconstitution hold conditions must be established by a qualified laboratory under a validated SOP; this page does not establish a stability window.
- Keep ambient-temperature handling time as short as practical to support compound integrity.
- Reseal vials promptly after each withdrawal to reduce moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.
Quality Assurance & Lab Verification
A finalized public Certificate of Analysis is available for this catalog item. Review the public COA for the applicable lot. Lot-specific identifiers, assay values, and methods are maintained in that record and are not repeated in this product dossier.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Laboratories should follow their validated SOP together with any handling fields published for the represented product or lot; no universal prepared-solution condition is inferred here.
Compound details.
- CAS Number
- 1208243-50-8
- Molecular Weight
- 1257.4 g/mol
- Class
- EPO-derived peptide (helix-B surface)
- Sequence length
- 11 residues
- Receptor target (research)
- Innate-repair receptor (CD131-containing complex)
Research context.
Studied in preclinical research models examining innate-repair receptor signaling, tissue-protection pathway research, and neuropathic / inflammatory model research. This context is limited to controlled research workflows.
Verification standard.
Certificate information is lot-specific. A finalized public record shows only the methods, fields, and results present for that named lot. A pending certificate state exposes no assay values and must not be interpreted as analytical verification. Review Nexus lab verification.
Analytical record.
- Reported HPLC purity
- 99.79%
- Retention time
- 10.00 min
- Observed mass
- 1257.43 Da
- Batch
- APX-2026-0414-C
The normalized Certificate of Analysis publishes only the lot-specific fields represented in the public record. It is not an originating laboratory report or raw instrument file.
View certificate of analysis - batch APX-2026-0414-C- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
Static molecular fallback shown because this catalog record does not include a sequence suitable for the amino-acid viewer.
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Ara-290 research FAQ.
What is Ara-290 used for in research?
Ara-290 is supplied for controlled in-vitro research workflows in the Specialty Research category. It is not labeled for human or veterinary use.
Does Ara-290 have a finalized analytical record?
Ara-290 has a finalized Nexus Lab Verified record that reports 99.79% HPLC area-percent purity for the represented batch. Other fields are shown only where present.
Which Ara-290 variants are published?
Published Nexus variants include 10mg.
Does Ara-290 include a COA?
Yes. The current Nexus record links Ara-290 to finalized batch APX-2026-0414-C.