Ara-290

Compound Overview

ARA290 (Cibinetide) is an 11-amino acid peptide derived from the helix B surface of erythropoietin (EPO). In research contexts, it selectively activates the Innate Repair Receptor (IRR), a heteromer of EPO receptor and CD131 (β-common receptor), without stimulating erythropoiesis. This receptor selectivity supports laboratory studies of tissue-protective signaling independent of red blood cell production.

Research Background & Published Literature

ARA290 has been discussed in Molecular Medicine and other journals, with published research covering neuroprotection, metabolic neuropathy, and anti-inflammatory signaling models. Clinical-trial literature has also investigated the compound in sarcoidosis and diabetic neuropathy contexts; Nexus supplies this catalog item only as an in-vitro research reagent and not for diagnostic, therapeutic, human, or veterinary use.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Brines et al. (2015) — Mol Med
• van Velzen et al. (2014) — Expert Opin Investig Drugs
• Zhang et al. (2016) — Peptides

Storage, Handling & Stability Guidelines

Store lyophilized ARA290 at -20°C for long-term stability. After reconstitution with sterile diluent, maintain material at 2–8°C and limit freeze-thaw exposure by aliquoting working volumes according to standard operating procedures.

• Keep ambient-temperature handling time as short as practical to support compound integrity.
• Reseal vials promptly after each withdrawal to reduce moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.