Glutathione

Compound Overview

Glutathione (GSH) is the most abundant intracellular antioxidant. This tripeptide is the primary substrate for the glutathione peroxidase and glutathione S-transferase enzyme families, and it is studied for its role in ROS neutralization, phase II detoxification, and cellular redox homeostasis.

Research Background & Published Literature

Glutathione is one of the most extensively studied compounds in redox biology, with tens of thousands of publications examining oxidative stress models, detoxification pathways, immune-function research, and cellular aging mechanisms. In controlled laboratory work, GSH levels are widely used as a biomarker of oxidative status.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Vašková et al. (2023) — Molecules
• Inoue (2016) — Arch Biochem Biophys
• Meister (1995) — Biochim Biophys Acta

Storage, Handling & Stability Guidelines

For material supplied in lyophilized form, maintain long-term storage at -20°C. After reconstitution with sterile diluent, keep preparations refrigerated at 2–8°C and limit freeze-thaw exposure by aliquoting working volumes according to your laboratory's standard operating procedures.

• Keep ambient-temperature handling time as short as practical to preserve compound integrity.
• Reseal vials promptly after each withdrawal to reduce moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.