IGF-1LR3

Compound Overview

IGF-1 LR3 (Long Arg3 IGF-1) is an 83-amino acid analog of insulin-like growth factor 1. Its structure includes an Arg substitution at position 3 and a 13-amino acid N-terminal extension. In research systems, these modifications are used to reduce IGFBP binding and increase bioavailability and potency relative to native IGF-1.

Research Background & Published Literature

IGF-1 LR3 is widely used as a cell-culture growth supplement and as a tool compound in IGF signaling research. Published work in Growth Hormone & IGF Research and Endocrinology has used this analog to examine IGF-1 receptor activation and downstream PI3K/Akt signaling in controlled laboratory models.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Laajoki et al. (1997) — FEBS Lett
• Kohler et al. (2010) — Growth Horm IGF Res
• Xi et al. (2004) — J Cell Physiol

Storage, Handling & Stability Guidelines

Store lyophilized IGF-1LR3 at -20°C for long-term stability. After reconstitution with sterile diluent, keep research material refrigerated at 2–8°C and minimize freeze-thaw cycles by aliquoting working volumes according to your standard operating procedures.

• Keep ambient-temperature exposure brief during handling to help preserve compound integrity.
• Reseal vials promptly after each withdrawal to reduce moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.