IGF-1LR3
IGF-1LR3 from the Nexus Growth Hormone Secretagogues catalog, supplied for controlled in-vitro research workflows.
Ships from the US with tracking.
Catalog active: Catalog pricing is active. Live warehouse counts are not published.
- Lot-specific COA
- HPLC + MS fields
- Batch archived
For in-vitro research use only. Not for human consumption.
IGF-1 LR3 (Long Arg3 IGF-1) is an 83-amino acid analog of insulin-like growth factor 1. Its structure includes an Arg substitution at position 3 and a 13-amino acid N-terminal extension. In research systems, these modifications are used to reduce IGFBP binding and increase bioavailability and potency relative to native IGF-1.
IGF-1LR3 definition
IGF-1 LR3 (Long Arg3 IGF-1) is an 83-amino acid analog of insulin-like growth factor 1 with two modifications: an Arg substitution at position 3 and a 13-amino acid N-terminal extension. These modifications reduce IGFBP binding, dramatically increasing bioavailability and potency compared to native IGF-1.
No sequence is listed in the current catalog record for this product.
- CAS
- 946870-92-4
- MW
- 9117.5 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- Not listed
- Purity
- 99.56%
- Form
- Not listed
- Class
- Growth Hormone Secretagogues
The dossier.
Compound Overview
IGF-1 LR3 (Long Arg3 IGF-1) is an 83-amino acid analog of insulin-like growth factor 1. Its structure includes an Arg substitution at position 3 and a 13-amino acid N-terminal extension. In research systems, these modifications are used to reduce IGFBP binding and increase bioavailability and potency relative to native IGF-1.
Research Background & Published Literature
IGF-1 LR3 is widely used as a cell-culture growth supplement and as a tool compound in IGF signaling research. Published work in Growth Hormone & IGF Research and Endocrinology has used this analog to examine IGF-1 receptor activation and downstream PI3K/Akt signaling in controlled laboratory models.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Laajoki et al. (1997) — FEBS Lett
- Kohler et al. (2010) — Growth Horm IGF Res
- Xi et al. (2004) — J Cell Physiol
Storage, Handling & Stability Guidelines
Use the applicable lot/source record for storage of unopened material. Any diluent selection, preparation, temperature, aliquoting, or post-reconstitution hold conditions must be established by a qualified laboratory under a validated SOP; this page does not establish a stability window.
- Keep ambient-temperature exposure brief during handling to help preserve compound integrity.
- Reseal vials promptly after each withdrawal to reduce moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.
Quality Assurance & Lab Verification
A finalized public Certificate of Analysis is available for this catalog item. Review the public COA for the applicable lot. Lot-specific identifiers, assay values, and methods are maintained in that record and are not repeated in this product dossier.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Laboratories should follow their validated SOP together with any handling fields published for the represented product or lot; no universal prepared-solution condition is inferred here.
Compound details.
- CAS Number
- 946870-92-4
- Molecular Weight
- 9117.5 g/mol
- Molecular Formula
- C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
- Class
- Long-Acting IGF-1 Analog
Research context.
Widely used in cell culture as a growth supplement and in IGF signaling research. Published in Growth Hormone & IGF Research and Endocrinology. Standard tool compound for studying IGF-1 receptor activation and downstream PI3K/Akt signaling.
Verification standard.
Certificate information is lot-specific. A finalized public record shows only the methods, fields, and results present for that named lot. A pending certificate state exposes no assay values and must not be interpreted as analytical verification. Review Nexus lab verification.
Analytical record.
- Reported HPLC purity
- 99.56%
- Retention time
- 18.50 min
- Observed mass
- 9117.44 Da
- Batch
- APX-2026-0416-I
The normalized Certificate of Analysis publishes only the lot-specific fields represented in the public record. It is not an originating laboratory report or raw instrument file.
View certificate of analysis - batch APX-2026-0416-I- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
Static molecular fallback shown because this catalog record does not include a sequence suitable for the amino-acid viewer.
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IGF-1LR3 research FAQ.
What is IGF-1LR3 used for in research?
IGF-1LR3 is supplied for controlled in-vitro research workflows in the Growth Hormone Secretagogues category. It is not labeled for human or veterinary use.
Does IGF-1LR3 have a finalized analytical record?
IGF-1LR3 has a finalized Nexus Lab Verified record that reports 99.56% HPLC area-percent purity for the represented batch. Other fields are shown only where present.
Which IGF-1LR3 variants are published?
Published Nexus variants include 0.1mg, 1mg.
Does IGF-1LR3 include a COA?
Yes. The current Nexus record links IGF-1LR3 to finalized batch APX-2026-0416-I.