Matrixyl

Compound Overview

Research Use Only. Not for Human Consumption.

Matrixyl is supplied by Nexus as a 10mg research catalog variant under SKU MA10. The supplied research record identifies Matrixyl as a palmitoylated cosmetic signal peptide and specifies the underlying molecule as palmitoyl pentapeptide-4, commonly written as Pal-KTTKS.

The source data describes Matrixyl as a cosmetic lipopeptide used in extracellular-matrix and dermal-fibroblast research workflows. That classification is included here only as research-context terminology. It does not imply human use, cosmetic application, topical use, therapeutic use, disease-related use, veterinary use, or dosing guidance.

This page is intentionally limited to the provided Nexus product data and the supplied Matrixyl research record. The source data provides the chemical name, classification, structural description, sequence notation, CAS number, molecular weight, molecular formula, physical form, storage guidance, intended-use language, and two background source links. It does not provide a purity percentage, batch number, COA release values, HPLC retention time, observed mass result, reconstitution solvent, solution-stability interval, supplier-specific assay conditions, or citation-level experimental endpoints. Those values are not inferred.

• Product: Matrixyl
• Available Research Size: 10mg
• SKU: MA10
• Catalog Category: Cosmetic & Skin
• Classification: Palmitoylated cosmetic signal peptide
• Structural Description: Palmitoyl pentapeptide-4, commonly written Pal-KTTKS, a palmitic-acid conjugated collagen-fragment signal peptide.
• Sequence: KTTKS
• Palmitoylated Sequence Display: Pal-Lys-Thr-Thr-Lys-Ser
• CAS Number: 214047-00-4
• Molecular Weight: 802.05 g/mol
• Molecular Formula: C₃₉H₇₅N₇O₁₀
• Physical Form: Lyophilized powder
• Use: For in-vitro research use only. Not for human consumption.

Research Background & Published Literature

The supplied research background notes an important labeling boundary: Matrixyl is a trade name, so final labeling should use the chemical name palmitoyl pentapeptide-4 and verify that the material corresponds to the Pal-KTTKS molecule rather than another Matrixyl-family peptide. Nexus applies that distinction by identifying this catalog item as palmitoyl pentapeptide-4 / Pal-KTTKS within the product record.

The structural description in the source record defines the compound as a palmitic-acid conjugated collagen-fragment signal peptide. The supplied sequence field lists KTTKS, while the sequence display field lists Pal-Lys-Thr-Thr-Lys-Ser. In practical catalog documentation, those two fields should be read together: the peptide sequence is KTTKS, and the Matrixyl molecule described here is the palmitoylated form, Pal-KTTKS.

The research file does not provide peer-reviewed citation details such as PubMed identifiers, DOI identifiers, journal names, publication dates, assay systems, cell models, exposure conditions, analytical methods, or quantitative endpoints. This section therefore stays at the level of compound identity, nomenclature, and source-record boundaries instead of adding mechanistic or outcome claims not present in the supplied data.

The supplied source list includes the following background references:

Those links are included because they appear in the supplied research record. This product description does not expand beyond the facts provided in the Nexus product and research data.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Robinson et al. (2005) — Int J Cosmet Sci
• Choi et al. (2014) — Biomol Ther (Seoul)

Storage, Handling & Stability Guidelines

The supplied storage guidance is to store lyophilized Matrixyl at -20°C, desiccated and protected from light. After reconstitution, the source record instructs laboratories to aliquot the material and avoid repeated freeze-thaw cycles.

• Store lyophilized material at -20°C.
• Keep the material desiccated during storage.
• Protect stored material from light exposure.
• After reconstitution, aliquot according to laboratory protocol.
• Avoid repeated freeze-thaw cycles after reconstitution.
• Maintain research records that connect aliquots to the original product name, SKU, and received lot documentation.

The supplied record does not specify a validated reconstitution solvent, target concentration, post-reconstitution expiration interval, container compatibility profile, acceptable freeze-thaw count, or formal stability-study result. Those details should be established from current lot documentation or a laboratory-validated protocol, not extrapolated from adjacent compounds.

Lab Verification

Nexus maintains research-compound verification records through the Lab Verified archive. In general terms, HPLC verification is used to evaluate chromatographic profile and purity-related characteristics, while MS verification is used to support molecular-identity confirmation where current lot documentation is available.

No exact Matrixyl COA values were provided in the current product record. The data does not include a batch number, purity percentage, HPLC chromatogram result, retention time, expected mass confirmation, observed mass result, release date, or analyst field. Researchers should review the current /lab-verified record and any available COA before incorporating Matrixyl into a controlled in-vitro workflow.