MT-2 (Melanotan 2 Acetate)

Compound Overview

Melanotan II, also referenced as MT-2, is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH). Research literature describes it as a non-selective agonist of melanocortin receptors MC1R through MC5R. Laboratory interest commonly focuses on MC1R activation in melanogenesis models, MC3R and MC4R involvement in metabolic and appetite regulation research, and related neuroendocrine signaling pathways.

Research Background & Published Literature

Originally developed at the University of Arizona, Melanotan II has been examined in melanogenesis, photoprotection research, and melanocortin signaling studies. Published work includes investigations into melanocortin receptor subtype selectivity and downstream cAMP signaling cascades.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Al-Obeidi et al. (1989) — J Med Chem
• Dorr et al. (1996) — Life Sci
• Ückert et al. (2014) — Expert Opin Investig Drugs

Storage, Handling & Stability Guidelines

The cyclic peptide structure provides enhanced stability compared to linear analogs. Store lyophilized material at -20°C. Reconstituted solutions should be held at 2–8°C and used within 30 days.

• Keep ambient-temperature exposure as brief as practical during handling to support compound integrity.
• Reseal vials promptly after each withdrawal to limit moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.