MT-1

Compound Overview

Melanotan I (afamelanotide), also listed as MT-1, is a linear tridecapeptide analog of α-melanocyte-stimulating hormone. In research literature, it demonstrates selectivity for the MC1R receptor relative to other melanocortin receptor subtypes, which makes it useful for studying melanogenesis signaling through MC1R-mediated pathways.

Research Background & Published Literature

Afamelanotide has been investigated in clinical research settings for erythropoietic protoporphyria (EPP) and is marketed under the brand name Scenesse in certain regions. Those references describe separate regulated clinical contexts; Nexus MT-1 is supplied only as a chemical research reagent and is not offered for human or therapeutic use. Laboratory research focuses on MC1R-selective signaling, eumelanin synthesis, and photoprotection pathways.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Sawyer et al. (1980) — Proc Natl Acad Sci U S A
• Langendonk et al. (2015) — N Engl J Med
• Minder et al. (2015) — Expert Rev Clin Pharmacol

Storage, Handling & Stability Guidelines

Keep lyophilized Melanotan I stored at -20°C for long-term holding. Because this compound has a linear peptide structure, it may be slightly less stable than cyclic analogs. After reconstitution, store research material at 2–8°C and use within 14 days.

• Keep ambient-temperature exposure as brief as practical during handling to support compound integrity.
• Reseal vials promptly after each withdrawal to limit moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.