MT-1

Compound Overview

Melanotan I (afamelanotide), also listed as MT-1, is a linear tridecapeptide analog of α-melanocyte-stimulating hormone. In research literature, it demonstrates selectivity for the MC1R receptor relative to other melanocortin receptor subtypes, which makes it useful for studying melanogenesis signaling through MC1R-mediated pathways.

Research Background & Published Literature

Afamelanotide has been investigated in clinical research settings for erythropoietic protoporphyria (EPP) and is marketed under the brand name Scenesse in certain regions. Those references describe separate regulated clinical contexts; Nexus MT-1 is supplied only as a chemical research reagent and is not offered for human or therapeutic use. Laboratory research focuses on MC1R-selective signaling, eumelanin synthesis, and photoprotection pathways.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Sawyer et al. (1980) — Proc Natl Acad Sci U S A
• Langendonk et al. (2015) — N Engl J Med
• Minder et al. (2015) — Expert Rev Clin Pharmacol

Storage, Handling & Stability Guidelines

Use the applicable lot/source record for storage of unopened material. Any diluent selection, preparation, temperature, aliquoting, or post-reconstitution hold conditions must be established by a qualified laboratory under a validated SOP; this page does not establish a stability window.

• Keep ambient-temperature exposure as brief as practical during handling to support compound integrity.
• Reseal vials promptly after each withdrawal to limit moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.

Quality Assurance & Lab Verification

A finalized public Certificate of Analysis is available for this catalog item. Review the public COA for the applicable lot. Lot-specific identifiers, assay values, and methods are maintained in that record and are not repeated in this product dossier.