KPV

Compound Overview

KPV is the C-terminal tripeptide fragment (Lys-Pro-Val) of alpha-melanocyte stimulating hormone (α-MSH). Although it does not bind melanocortin receptors, KPV is studied for anti-inflammatory signaling associated with NF-κB pathway inhibition and PGE2 reduction. Research literature evaluates its immunomodulatory properties apart from melanocortin receptor activity.

Research Background & Published Literature

KPV appears in published work from Annals of the New York Academy of Sciences and FEBS Letters. Controlled research has examined the tripeptide in inflammatory bowel disease models, intestinal inflammation studies, and immune modulation experiments.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Dalmasso et al. (2008) — Gastroenterology
• Viennois et al. (2016) — Cell Mol Gastroenterol Hepatol
• Xiao et al. (2017) — Mol Ther

Storage, Handling & Stability Guidelines

For long-term stability, keep lyophilized KPV stored at -20°C. After reconstitution with sterile diluent, refrigerate at 2–8°C and reduce repeated freeze-thaw exposure by aliquoting working volumes according to your laboratory's standard operating procedures.

• Keep ambient-temperature handling time as short as practical to support compound integrity.
• Reseal vials promptly after each withdrawal to reduce moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.