TB500 (Thymosin B4 Acetate)
TB500 (Thymosin B4 Acetate) from the Nexus Healing & Recovery catalog, supplied for controlled in-vitro research workflows.
Ships from the US with tracking.
Catalog active: Catalog pricing is active. Live warehouse counts are not published.
- Lot-specific COA
- HPLC + MS fields
- Batch archived
For in-vitro research use only. Not for human consumption.
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein involved in actin regulation and cell migration. TB-500 binds G-actin (monomeric actin) and promotes actin polymerization, which is central to cell motility, cytoskeletal organization, and tissue remodeling in research models.
No sequence is listed in the current catalog record for this product.
- CAS
- 77591-33-4
- MW
- 4963.50 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C212H350N56O78S
- Purity
- 99.48%
- Form
- Lyophilized powder
- Class
- Thymosin Beta-4 Fragment
The dossier.
Compound Overview
TB-500 is a synthetic peptide aligned with the active region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein associated with actin regulation and cell migration in laboratory models. The peptide binds G-actin (monomeric actin) and promotes actin polymerization, a mechanism central to cell motility, cytoskeletal organization, and tissue remodeling research.
Research Background & Published Literature
Thymosin Beta-4 and active fragments derived from it have been studied across wound repair models, angiogenesis research, anti-inflammatory signaling work, and cardiac tissue research. Literature in journals such as Annals of the New York Academy of Sciences and FASEB Journal describes actin-binding behavior and downstream signaling effects under controlled experimental conditions.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Yu et al. (1993) — J Biol Chem
- Hannappel (2007) — Ann N Y Acad Sci
- Shrivastava et al. (2010) — Ann N Y Acad Sci
Storage, Handling & Stability Guidelines
Use the applicable lot/source record for storage of unopened material. Any diluent selection, preparation, temperature, aliquoting, or post-reconstitution hold conditions must be established by a qualified laboratory under a validated SOP; this page does not establish a stability window.
- Keep ambient-temperature handling time as short as practical to support compound integrity.
- Reseal vials promptly after each withdrawal to reduce moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.
Quality Assurance & Lab Verification
A finalized public Certificate of Analysis is available for this catalog item. Review the public COA for the applicable lot. Lot-specific identifiers, assay values, and methods are maintained in that record and are not repeated in this product dossier.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Laboratories should follow their validated SOP together with any handling fields published for the represented product or lot; no universal prepared-solution condition is inferred here.
Compound details.
- CAS Number
- 77591-33-4
- Molecular Weight
- 4963.50 g/mol
- Molecular Formula
- C₂₁₂H₃₅₀N₅₆O₇₈S
- Class
- Thymosin Beta-4 Fragment
Research context.
Thymosin Beta-4 and its active fragments have been extensively studied for their roles in wound repair models, angiogenesis, anti-inflammatory signaling, and cardiac tissue research. Published studies in journals including Annals of the New York Academy of Sciences and FASEB Journal have characterized its actin-binding properties and downstream signaling effects.
Verification standard.
Certificate information is lot-specific. A finalized public record shows only the methods, fields, and results present for that named lot. A pending certificate state exposes no assay values and must not be interpreted as analytical verification. Review Nexus lab verification.
Analytical record.
- Reported HPLC purity
- 99.48%
- Retention time
- 16.20 min
- Observed mass
- 4963.72 Da
- Batch
- APX-2026-0413-T
The normalized Certificate of Analysis publishes only the lot-specific fields represented in the public record. It is not an originating laboratory report or raw instrument file.
View certificate of analysis - batch APX-2026-0413-T- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
43-amino acid peptide, synthetic fragment of Thymosin Beta-4
Technical specifications.
- Product Name: TB-500
- Classification: Thymosin Beta-4 Fragment
- Structural Description: 43-amino acid peptide, synthetic fragment of Thymosin Beta-4
- CAS Number: 77591-33-4
- Molecular Weight: 4963.50 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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Research notes.
TB500 (Thymosin B4 Acetate) research FAQ.
What is TB500 (Thymosin B4 Acetate) used for in research?
TB500 (Thymosin B4 Acetate) is supplied for controlled in-vitro research workflows in the Healing & Recovery category. It is not labeled for human or veterinary use.
Does TB500 (Thymosin B4 Acetate) have a finalized analytical record?
TB500 (Thymosin B4 Acetate) has a finalized Nexus Lab Verified record that reports 99.48% HPLC area-percent purity for the represented batch. Other fields are shown only where present.
Which TB500 (Thymosin B4 Acetate) variants are published?
Published Nexus variants include 2mg, 5mg, 10mg, 20mg.
Does TB500 (Thymosin B4 Acetate) include a COA?
Yes. The current Nexus record links TB500 (Thymosin B4 Acetate) to finalized batch APX-2026-0413-T.