TB500 (Thymosin B4 Acetate)
TB500 (Thymosin B4 Acetate) from the Nexus Healing & Recovery catalog, supplied for controlled in-vitro research workflows.
In stock: 2mg is in stock.
For in-vitro research use only. Not for human consumption.
TB-500 is a synthetic peptide corresponding to the active region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein involved in actin regulation and cell migration. TB-500 binds G-actin (monomeric actin) and promotes actin polymerization, which is central to cell motility, cytoskeletal organization, and tissue remodeling in research models.
No sequence is listed in the current catalog record for this product.
- CAS
- 77591-33-4
- MW
- 4963.50 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C212H350N56O78S
- Purity
- 99.48%
- Form
- Lyophilized powder
- Class
- Thymosin Beta-4 Fragment
This lyophilized research material is commonly paired with bacteriostatic water for reconstitution workflows.
Bacteriostatic water for reconstitutionThe dossier.
Compound Overview
TB-500 is a synthetic peptide aligned with the active region of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino acid protein associated with actin regulation and cell migration in laboratory models. The peptide binds G-actin (monomeric actin) and promotes actin polymerization, a mechanism central to cell motility, cytoskeletal organization, and tissue remodeling research.
Research Background & Published Literature
Thymosin Beta-4 and active fragments derived from it have been studied across wound repair models, angiogenesis research, anti-inflammatory signaling work, and cardiac tissue research. Literature in journals such as Annals of the New York Academy of Sciences and FASEB Journal describes actin-binding behavior and downstream signaling effects under controlled experimental conditions.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Yu et al. (1993) — J Biol Chem
- Hannappel (2007) — Ann N Y Acad Sci
- Shrivastava et al. (2010) — Ann N Y Acad Sci
Storage, Handling & Stability Guidelines
For long-term stability, keep lyophilized TB-500 stored at -20°C. After reconstitution with bacteriostatic water, refrigerate at 2–8°C and use within 14 days. Aliquoting is recommended to reduce repeated freeze-thaw cycles.
- Keep ambient-temperature handling time as short as practical to support compound integrity.
- Reseal vials promptly after each withdrawal to reduce moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.
Lab Verification
Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Compounds are supplied as lyophilized research material — follow the storage and reconstitution guidance on the product page and its Certificate of Analysis.
Compound details.
- CAS Number
- 77591-33-4
- Molecular Weight
- 4963.50 g/mol
- Molecular Formula
- C₂₁₂H₃₅₀N₅₆O₇₈S
- Class
- Thymosin Beta-4 Fragment
- Purity
- ≥99% purity
- Physical Form
- Lyophilized powder
- Storage
- Store at -20°C (long term). Refrigerate after reconstitution.
Research context.
Thymosin Beta-4 and its active fragments have been extensively studied for their roles in wound repair models, angiogenesis, anti-inflammatory signaling, and cardiac tissue research. Published studies in journals including Annals of the New York Academy of Sciences and FASEB Journal have characterized its actin-binding properties and downstream signaling effects.
Verification standard.
Independently verified Nexus Laboratory batches ship with a Certificate of Analysis documenting HPLC purity (target ≥98%), mass spectrometry identity (expected versus observed mass), and endotoxin context where applicable — verified by independent third-party laboratories and publicly archived; lots awaiting final documentation are labeled certificate pending instead of showing assay values. Review Nexus lab verification.
HPLC trace.
- HPLC purity
- 99.48%
- Retention time
- 16.2 min
- Batch
- NEX-TB500-THYMOSIN-B4-ACETATE-2026-0086
The full reverse-phase HPLC chromatogram, peak integration table, and mass-spectrometry identity confirmation for this batch are published on the certificate of analysis.
View certificate of analysis - batch NEX-TB500-THYMOSIN-B4-ACETATE-2026-0086- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
43-amino acid peptide, synthetic fragment of Thymosin Beta-4
Storage: Store at -20°C (long term). Refrigerate after reconstitution.
Technical specifications.
- Product Name: TB-500
- Classification: Thymosin Beta-4 Fragment
- Structural Description: 43-amino acid peptide, synthetic fragment of Thymosin Beta-4
- CAS Number: 77591-33-4
- Molecular Weight: 4963.50 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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Research notes.
TB500 (Thymosin B4 Acetate) research FAQ.
What is TB500 (Thymosin B4 Acetate) used for in research?
TB500 (Thymosin B4 Acetate) is supplied for controlled in-vitro research workflows in the Healing & Recovery category. It is not labeled for human or veterinary use.
Is TB500 (Thymosin B4 Acetate) HPLC verified?
TB500 (Thymosin B4 Acetate) has a finalized Nexus Lab Verified record with 99.48% HPLC purity context in the current COA data.
Which TB500 (Thymosin B4 Acetate) sizes are available?
Current Nexus variants include 2mg, 5mg, 10mg, 20mg.
Does TB500 (Thymosin B4 Acetate) include a COA?
Yes. The current Nexus record links TB500 (Thymosin B4 Acetate) to verified batch NEX-TB500-THYMOSIN-B4-ACETATE-2026-0086.