Epithalon

Compound Overview

Epithalon (Epitalon) is a synthetic tetrapeptide analog of epithalamin, a naturally occurring pineal gland peptide. In controlled research models, investigators examine its role in telomerase (hTERT) activation, the enzyme system responsible for maintaining telomere length. It is also studied in relation to melatonin synthesis and circadian rhythm signaling.

Research Background & Published Literature

Prof. Vladimir Khavinson developed Epithalon at the Saint Petersburg Institute of Bioregulation and Gerontology. Published studies in Bulletin of Experimental Biology and Medicine and Neuroendocrinology Letters have evaluated telomerase activation and bioregulatory peptide signaling in laboratory research contexts.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Khavinson VKh et al. (2003) — Bull Exp Biol Med
• Khavinson VKh et al. (2004) — Bull Exp Biol Med
• Araj et al. (2025) — Int J Mol Sci

Storage, Handling & Stability Guidelines

For long-term stability, store lyophilized material at -20°C. After reconstitution with sterile diluent, keep the preparation refrigerated at 2–8°C and reduce freeze-thaw exposure by aliquoting working volumes according to your laboratory's standard operating procedures.

• Keep ambient-temperature handling time as short as practical to support compound integrity.
• Reseal vials promptly after each withdrawal to limit moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.