FOXO4

Compound Overview

FOXO4-DRI is a D-retro-inverso peptide designed to disrupt the interaction between FOXO4 and p53 transcription factors. In senescent-cell research models, FOXO4 binds p53 to prevent apoptosis. Disrupting this interaction with FOXO4-DRI allows researchers to study p53-triggered apoptosis in senescent cells while sparing normal cells, making it a research tool for selective senolysis.

Research Background & Published Literature

A Cell publication from Baar et al. (2017), authored by researchers at Erasmus University Medical Center, demonstrated selective elimination of senescent cells in aged mouse models and helped drive broader interest in senolytics research.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Baar et al. (2017) — Cell
• Alameen et al. (2026) — Naunyn Schmiedebergs Arch Pharmacol

Storage, Handling & Stability Guidelines

For long-term stability, store lyophilized FOXO4-DRI material at -20°C. After reconstitution with sterile diluent, keep the preparation refrigerated at 2–8°C and limit freeze-thaw exposure by aliquoting working volumes according to your laboratory's standard operating procedures.

• Keep ambient-temperature handling time as short as practical to support compound integrity.
• Reseal vials promptly after each withdrawal to limit moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.