Humanin

Compound Overview

Humanin is a 24-amino acid peptide encoded within the mitochondrial 16S rRNA gene and is recognized as the founding member of the mitochondrial-derived peptide (MDP) family. Laboratory research evaluates Humanin in relation to cytoprotective signaling through STAT3 signaling, IGFBP-3 binding, and BAX-mediated apoptosis inhibition pathways.

Research Background & Published Literature

Humanin was discovered in 2001 and has appeared in peer-reviewed publications including PNAS, Cell Metabolism, and Aging Cell. Controlled research examines Humanin in the context of neuroprotection, mitochondrial signaling, and cellular stress response, with MOTS-c often used as a related mitochondrial-derived signaling peptide for comparison.

Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:

• Hashimoto et al. (2001) — Proc Natl Acad Sci U S A
• Hashimoto et al. (2001) — J Neurosci
• Sivakumar et al. (2026) — Curr Cardiol Rev

Storage, Handling & Stability Guidelines

Store lyophilized Humanin at -20°C for long-term stability. After reconstitution with sterile diluent, keep the research material refrigerated at 2–8°C and minimize freeze-thaw cycles by aliquoting working volumes according to your standard operating procedures.

• Keep time at ambient temperature as brief as practical during handling to support compound integrity.
• Reseal vials promptly after each withdrawal to limit moisture exposure.
• Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
• For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.

Lab Verification

Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.