SS-31
SS-31 from the Nexus Longevity & Cellular Health catalog, supplied for controlled in-vitro research workflows.
In stock: 10mg is in stock.
For in-vitro research use only. Not for human consumption.
SS-31 (Elamipretide) is a cell-permeable tetrapeptide that selectively concentrates in the inner mitochondrial membrane by binding cardiolipin. This interaction stabilizes cytochrome c and optimizes electron transport chain function, reducing mitochondrial ROS production. It is the most studied mitochondria-targeted peptide.
No sequence is listed in the current catalog record for this product.
- CAS
- 736992-21-5
- MW
- 640.77 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C32H49N9O5
- Purity
- 99.54%
- Form
- Lyophilized powder
- Class
- Mitochondria-Targeted Antioxidant Peptide
This lyophilized research material is commonly paired with bacteriostatic water for reconstitution workflows.
Browse bacteriostatic waterThe dossier.
Compound Overview
SS-31 (Elamipretide) is a cell-permeable tetrapeptide that selectively concentrates in the inner mitochondrial membrane through cardiolipin binding. In laboratory research, this interaction is described as stabilizing cytochrome c, optimizing electron transport chain function, and reducing mitochondrial ROS production. SS-31 is described as the most studied mitochondria-targeted peptide.
Research Background & Published Literature
SS-31 was developed by Dr. Hazel Szeto, with published work appearing in Clinical Pharmacology & Therapeutics and JACC. The broader research literature includes clinical-research programs in heart failure (TANGO), Barth syndrome, and age-related mitochondrial dysfunction. Nexus provides this background for literature review only; this product is not supplied for clinical, therapeutic, human, or veterinary use.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Petri et al. (2006) — J Neurochem
- Mizuguchi et al. (2008) — Am J Physiol Renal Physiol
- Tung et al. (2025) — Int J Mol Sci
Storage, Handling & Stability Guidelines
For long-term stability, store lyophilized SS-31 material at -20°C. After reconstitution with sterile diluent, keep the material refrigerated at 2–8°C and limit freeze-thaw exposure by aliquoting working volumes according to your laboratory's standard operating procedures.
- Keep ambient-temperature handling time as short as practical to support compound integrity.
- Reseal vials promptly after each withdrawal to limit moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label aliquots with compound name, concentration, reconstitution date, and operator initials.
Lab Verification
Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Compounds are supplied as lyophilized research material — follow the storage and reconstitution guidance on the product page and its Certificate of Analysis.
Compound details.
- CAS Number
- 736992-21-5
- Molecular Weight
- 640.77 g/mol
- Molecular Formula
- C₃₂H₄₉N₉O₅
- Class
- Mitochondria-Targeted Antioxidant Peptide
- Purity
- ≥99% purity
- Physical Form
- Lyophilized powder
- Storage
- Store at -20°C (long term). Refrigerate after reconstitution.
Research context.
Developed by Dr. Hazel Szeto. Published in Clinical Pharmacology & Therapeutics and JACC. Clinical trials have investigated it in heart failure (TANGO), Barth syndrome, and age-related mitochondrial dysfunction. A key research tool for studying mitochondrial medicine.
Verification standard.
Independently verified Nexus Laboratory batches ship with a Certificate of Analysis documenting HPLC purity (target ≥98%), mass spectrometry identity (expected versus observed mass), and endotoxin context where applicable — verified by independent third-party laboratories and publicly archived; lots awaiting final documentation are labeled certificate pending instead of showing assay values. Review Nexus lab verification.
HPLC trace.
- HPLC purity
- 99.54%
- Retention time
- 7 min
- Batch
- NEX-SS-31-2026-0083
The full reverse-phase HPLC chromatogram, peak integration table, and mass-spectrometry identity confirmation for this batch are published on the certificate of analysis.
View certificate of analysis - batch NEX-SS-31-2026-0083- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
4-amino acid peptide (D-Arg-Dmt-Lys-Phe-NH2), also known as Elamipretide/Bendavia
Storage: Store at -20°C (long term). Refrigerate after reconstitution.
Technical specifications.
- Product Name: SS-31
- Classification: Mitochondria-Targeted Antioxidant Peptide
- Structural Description: 4-amino acid peptide (D-Arg-Dmt-Lys-Phe-NH2), also known as Elamipretide/Bendavia
- CAS Number: 736992-21-5
- Molecular Weight: 640.77 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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SS-31 research FAQ.
What is SS-31 used for in research?
SS-31 is supplied for controlled in-vitro research workflows in the Longevity & Cellular Health category. It is not labeled for human or veterinary use.
Is SS-31 HPLC verified?
SS-31 has a finalized Nexus Lab Verified record with 99.54% HPLC purity context in the current COA data.
Which SS-31 sizes are available?
Current Nexus variants include 10mg, 50mg.
Does SS-31 include a COA?
Yes. The current Nexus record links SS-31 to verified batch NEX-SS-31-2026-0083.