SS-31
SS-31 from the Nexus Longevity & Cellular Health catalog, supplied for controlled in-vitro research workflows.
Ships from the US with tracking.
Catalog active: Catalog pricing is active. Live warehouse counts are not published.
- Lot-specific COA
- HPLC + MS fields
- Batch archived
For in-vitro research use only. Not for human consumption.
SS-31 (Elamipretide) is a cell-permeable tetrapeptide that selectively concentrates in the inner mitochondrial membrane by binding cardiolipin. This interaction stabilizes cytochrome c and optimizes electron transport chain function, reducing mitochondrial ROS production. It is the most studied mitochondria-targeted peptide.
No sequence is listed in the current catalog record for this product.
- CAS
- 736992-21-5
- MW
- 640.77 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C32H49N9O5
- Purity
- 99.54%
- Form
- Lyophilized powder
- Class
- Mitochondria-Targeted Antioxidant Peptide
The dossier.
Compound Overview
SS-31 (Elamipretide) is a cell-permeable tetrapeptide that selectively concentrates in the inner mitochondrial membrane through cardiolipin binding. In laboratory research, this interaction is described as stabilizing cytochrome c, optimizing electron transport chain function, and reducing mitochondrial ROS production. SS-31 is described as the most studied mitochondria-targeted peptide.
Research Background & Published Literature
SS-31 was developed by Dr. Hazel Szeto, with published work appearing in Clinical Pharmacology & Therapeutics and JACC. The broader research literature includes clinical-research programs in heart failure (TANGO), Barth syndrome, and age-related mitochondrial dysfunction. Nexus provides this background for literature review only; this product is not supplied for clinical, therapeutic, human, or veterinary use.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Petri et al. (2006) — J Neurochem
- Mizuguchi et al. (2008) — Am J Physiol Renal Physiol
- Tung et al. (2025) — Int J Mol Sci
Storage, Handling & Stability Guidelines
Use the applicable lot/source record for storage of unopened material. Any diluent selection, preparation, temperature, aliquoting, or post-reconstitution hold conditions must be established by a qualified laboratory under a validated SOP; this page does not establish a stability window.
- Keep ambient-temperature handling time as short as practical to support compound integrity.
- Reseal vials promptly after each withdrawal to limit moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label aliquots with compound name, concentration, reconstitution date, and operator initials.
Quality Assurance & Lab Verification
A finalized public Certificate of Analysis is available for this catalog item. Review the public COA for the applicable lot. Lot-specific identifiers, assay values, and methods are maintained in that record and are not repeated in this product dossier.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Laboratories should follow their validated SOP together with any handling fields published for the represented product or lot; no universal prepared-solution condition is inferred here.
Compound details.
- CAS Number
- 736992-21-5
- Molecular Weight
- 640.77 g/mol
- Molecular Formula
- C₃₂H₄₉N₉O₅
- Class
- Mitochondria-Targeted Antioxidant Peptide
Research context.
Developed by Dr. Hazel Szeto. Published in Clinical Pharmacology & Therapeutics and JACC. Clinical trials have investigated it in heart failure (TANGO), Barth syndrome, and age-related mitochondrial dysfunction. A key research tool for studying mitochondrial medicine.
Verification standard.
Certificate information is lot-specific. A finalized public record shows only the methods, fields, and results present for that named lot. A pending certificate state exposes no assay values and must not be interpreted as analytical verification. Review Nexus lab verification.
Analytical record.
- Reported HPLC purity
- 99.54%
- Retention time
- 7.00 min
- Observed mass
- 639.97 Da
- Batch
- APX-2026-0321-E
The normalized Certificate of Analysis publishes only the lot-specific fields represented in the public record. It is not an originating laboratory report or raw instrument file.
View certificate of analysis - batch APX-2026-0321-E- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
4-amino acid peptide (D-Arg-Dmt-Lys-Phe-NH2), also known as Elamipretide/Bendavia
Technical specifications.
- Product Name: SS-31
- Classification: Mitochondria-Targeted Antioxidant Peptide
- Structural Description: 4-amino acid peptide (D-Arg-Dmt-Lys-Phe-NH2), also known as Elamipretide/Bendavia
- CAS Number: 736992-21-5
- Molecular Weight: 640.77 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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SS-31 research FAQ.
What is SS-31 used for in research?
SS-31 is supplied for controlled in-vitro research workflows in the Longevity & Cellular Health category. It is not labeled for human or veterinary use.
Does SS-31 have a finalized analytical record?
SS-31 has a finalized Nexus Lab Verified record that reports 99.54% HPLC area-percent purity for the represented batch. Other fields are shown only where present.
Which SS-31 variants are published?
Published Nexus variants include 10mg, 50mg.
Does SS-31 include a COA?
Yes. The current Nexus record links SS-31 to finalized batch APX-2026-0321-E.