LL37
LL37 from the Nexus Healing & Recovery catalog, supplied for controlled in-vitro research workflows.
In stock: 5mg is in stock.
For in-vitro research use only. Not for human consumption.
LL-37 is the only human cathelicidin, a 37-amino acid alpha-helical peptide processed from the precursor protein hCAP18. It exhibits broad-spectrum antimicrobial activity through membrane disruption and also functions as an immunomodulator, chemokine, and angiogenesis factor. Research examines its roles in innate immunity, wound healing, and biofilm disruption.
LL37 definition
LL-37 is the active 37-amino-acid C-terminal cathelicidin antimicrobial peptide derived from the human cathelicidin precursor protein hCAP-18. Research models examine its broad-spectrum antimicrobial activity, role in innate immunity, and interactions with mammalian cell membranes. The peptide is alpha-helical in membrane environments. Research use only. Independently verified Nexus lots publish a Certificate of Analysis documenting HPLC purity, mass spectrometry identity, and endotoxin screening; pending lots are labeled certificate pending.
No sequence is listed in the current catalog record for this product.
- CAS
- 154947-66-7
- MW
- 4493.33 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C205H340N60O53
- Purity
- 99.81%
- Form
- Lyophilized powder
- Class
- Cathelicidin Antimicrobial Peptide (CAMP)
This lyophilized research material is commonly paired with bacteriostatic water for reconstitution workflows.
Bacteriostatic water for reconstitutionThe dossier.
Compound Overview
LL-37 is the only human cathelicidin, a 37-amino acid alpha-helical peptide generated from the hCAP18 precursor protein. Laboratory studies examine its broad-spectrum antimicrobial activity through membrane disruption, along with its reported functions as an immunomodulator, chemokine, and angiogenesis factor. Controlled research also evaluates LL-37 in innate-immunity models, wound-healing research, and biofilm-disruption experiments.
Research Background & Published Literature
LL-37 is a widely cited host-defense peptide in the peer-reviewed literature, with studies appearing across Journal of Immunology, PNAS, and Antimicrobial Agents and Chemotherapy. Researchers use the compound as a tool for studying innate immunity, host defense peptide biology, antimicrobial resistance models, and related in-vitro signaling systems.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Turner et al. (1998) — Antimicrob Agents Chemother
- Koczulla et al. (2003) — J Clin Invest
- Wang et al. (2014) — Biochim Biophys Acta
Storage, Handling & Stability Guidelines
For long-term stability, keep lyophilized LL-37 stored at -20°C. After reconstitution with sterile diluent, refrigerate at 2–8°C and reduce repeated freeze-thaw exposure by aliquoting working volumes according to your laboratory's standard operating procedures.
- Keep ambient-temperature handling time as short as practical to support compound integrity.
- Reseal vials promptly after each withdrawal to reduce moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.
Lab Verification
Nexus maintains batch-level verification records for research compounds in the Lab Verified archive, including HPLC purity review and Mass Spectrometry identity confirmation where current lot data is available.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Compounds are supplied as lyophilized research material — follow the storage and reconstitution guidance on the product page and its Certificate of Analysis.
Compound details.
- CAS Number
- 154947-66-7
- Molecular Weight
- 4493.3 g/mol
- Class
- Cathelicidin antimicrobial peptide
- Sequence length
- 37 residues
- Structural class
- Alpha-helical amphipathic peptide
Research context.
Studied in preclinical research models examining antimicrobial peptide pharmacology, innate-immune signaling research, membrane-interaction research, and wound-healing-related innate-immunity research models. Research use only.
Verification standard.
Independently verified Nexus Laboratory batches ship with a Certificate of Analysis documenting HPLC purity (target ≥98%), mass spectrometry identity (expected versus observed mass), and endotoxin context where applicable — verified by independent third-party laboratories and publicly archived; lots awaiting final documentation are labeled certificate pending instead of showing assay values. Review Nexus lab verification.
HPLC trace.
- HPLC purity
- 99.81%
- Retention time
- 17.5 min
- Batch
- NEX-LL37-2026-0050
The full reverse-phase HPLC chromatogram, peak integration table, and mass-spectrometry identity confirmation for this batch are published on the certificate of analysis.
View certificate of analysis - batch NEX-LL37-2026-0050- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
The chemistry.
37-amino acid human cathelicidin antimicrobial peptide
Storage: Store at -20°C (long term). Refrigerate after reconstitution.
Technical specifications.
- Product Name: LL-37 5mg
- Classification: Cathelicidin Antimicrobial Peptide (CAMP)
- Structural Description: 37-amino acid human cathelicidin antimicrobial peptide
- CAS Number: 154947-66-7
- Molecular Weight: 4493.33 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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LL37 research FAQ.
What is LL37 used for in research?
LL37 is supplied for controlled in-vitro research workflows in the Healing & Recovery category. It is not labeled for human or veterinary use.
Is LL37 HPLC verified?
LL37 has a finalized Nexus Lab Verified record with 99.81% HPLC purity context in the current COA data.
Which LL37 sizes are available?
Current Nexus variants include 5mg.
Does LL37 include a COA?
Yes. The current Nexus record links LL37 to verified batch NEX-LL37-2026-0050.