LL37
LL37 from the Nexus Healing & Recovery catalog, supplied for controlled in-vitro research workflows.
Ships from the US with tracking.
Catalog active: Catalog pricing is active. Live warehouse counts are not published.
- Lot-specific COA
- HPLC + MS fields
- Batch archived
For in-vitro research use only. Not for human consumption.
LL-37 is the only human cathelicidin, a 37-amino acid alpha-helical peptide processed from the precursor protein hCAP18. It exhibits broad-spectrum antimicrobial activity through membrane disruption and also functions as an immunomodulator, chemokine, and angiogenesis factor. Research examines its roles in innate immunity, wound healing, and biofilm disruption.
LL37 definition
LL-37 is the active 37-amino-acid C-terminal cathelicidin antimicrobial peptide derived from the human cathelicidin precursor protein hCAP-18. Research models examine its broad-spectrum antimicrobial activity, role in innate immunity, and interactions with mammalian cell membranes. The peptide is alpha-helical in membrane environments. Research use only.
No sequence is listed in the current catalog record for this product.
- CAS
- 154947-66-7
- MW
- 4493.33 g/mol
- Sequence
- Not listed
- Half-life
- Not listed
- Formula
- C205H340N60O53
- Purity
- 99.81%
- Form
- Lyophilized powder
- Class
- Cathelicidin Antimicrobial Peptide (CAMP)
The dossier.
Compound Overview
LL-37 is the only human cathelicidin, a 37-amino acid alpha-helical peptide generated from the hCAP18 precursor protein. Laboratory studies examine its broad-spectrum antimicrobial activity through membrane disruption, along with its reported functions as an immunomodulator, chemokine, and angiogenesis factor. Controlled research also evaluates LL-37 in innate-immunity models, wound-healing research, and biofilm-disruption experiments.
Research Background & Published Literature
LL-37 is a widely cited host-defense peptide in the peer-reviewed literature, with studies appearing across Journal of Immunology, PNAS, and Antimicrobial Agents and Chemotherapy. Researchers use the compound as a tool for studying innate immunity, host defense peptide biology, antimicrobial resistance models, and related in-vitro signaling systems.
Researchers reviewing the literature around this compound can use the peer-reviewed resources below for additional context on mechanism of action, signaling pathways, and controlled laboratory research applications:
- Turner et al. (1998) — Antimicrob Agents Chemother
- Koczulla et al. (2003) — J Clin Invest
- Wang et al. (2014) — Biochim Biophys Acta
Storage, Handling & Stability Guidelines
Use the applicable lot/source record for storage of unopened material. Any diluent selection, preparation, temperature, aliquoting, or post-reconstitution hold conditions must be established by a qualified laboratory under a validated SOP; this page does not establish a stability window.
- Keep ambient-temperature handling time as short as practical to support compound integrity.
- Reseal vials promptly after each withdrawal to reduce moisture exposure.
- Use appropriate personal protective equipment and follow institutional chemical safety protocols at all times.
- For traceability, label all aliquots with compound name, concentration, reconstitution date, and operator initials.
Quality Assurance & Lab Verification
A finalized public Certificate of Analysis is available for this catalog item. Review the public COA for the applicable lot. Lot-specific identifiers, assay values, and methods are maintained in that record and are not repeated in this product dossier.
Shipping
Orders ship within the United States via USPS; international orders are not accepted. Laboratories should follow their validated SOP together with any handling fields published for the represented product or lot; no universal prepared-solution condition is inferred here.
Compound details.
- CAS Number
- 154947-66-7
- Molecular Weight
- 4493.3 g/mol
- Class
- Cathelicidin antimicrobial peptide
- Sequence length
- 37 residues
- Structural class
- Alpha-helical amphipathic peptide
Research context.
Studied in preclinical research models examining antimicrobial peptide pharmacology, innate-immune signaling research, membrane-interaction research, and wound-healing-related innate-immunity research models. Research use only.
Verification standard.
Certificate information is lot-specific. A finalized public record shows only the methods, fields, and results present for that named lot. A pending certificate state exposes no assay values and must not be interpreted as analytical verification. Review Nexus lab verification.
Analytical record.
- Reported HPLC purity
- 99.81%
- Retention time
- 17.50 min
- Observed mass
- 4493.32 Da
- Batch
- APX-2026-0312-L
The normalized Certificate of Analysis publishes only the lot-specific fields represented in the public record. It is not an originating laboratory report or raw instrument file.
View certificate of analysis - batch APX-2026-0312-L- Sequence
- Not listed
- Model preview
- Unavailable
Molecular model preview is unavailable for this catalog record.
Technical specifications.
- Product Name: LL-37 5mg
- Classification: Cathelicidin Antimicrobial Peptide (CAMP)
- Structural Description: 37-amino acid human cathelicidin antimicrobial peptide
- CAS Number: 154947-66-7
- Molecular Weight: 4493.33 g/mol
- Purity: ≥99% (verified by HPLC and Mass Spectrometry)
- Physical Form: Lyophilized (freeze-dried) powder
- Intended Use: In-vitro research use only — not for human consumption
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LL37 research FAQ.
What is LL37 used for in research?
LL37 is supplied for controlled in-vitro research workflows in the Healing & Recovery category. It is not labeled for human or veterinary use.
Does LL37 have a finalized analytical record?
LL37 has a finalized Nexus Lab Verified record that reports 99.81% HPLC area-percent purity for the represented batch. Other fields are shown only where present.
Which LL37 variants are published?
Published Nexus variants include 5mg.
Does LL37 include a COA?
Yes. The current Nexus record links LL37 to finalized batch APX-2026-0312-L.